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Italian oncologists and vaccinations against infectious diseases: Results of a survey of the Italian Association of Medical Oncology
CONCLUSION: This is the first survey conducted among Italian oncologists to better understand the perception and attitudes towards the vaccination. It highlights the urgent issues of educating and training oncologists in vaccine-preventable diseases and vaccine awareness and the need to build (or implement) a network of multidisciplinary collaborations.PMID:37586016 | DOI:10.1177/03008916231191547
Source: Herpes - August 16, 2023 Category: Infectious Diseases Authors: Angioletta Lasagna Antonella Brunello Nicola Silvestris Paolo Pedrazzoli Massimo Di Maio Saverio Cinieri Source Type: research

Applying the COM-B behaviour model to understand factors which impact school immunisation nurses' attitudes towards designing and delivering a HPV educational intervention in post-primary schools for 15-17  year old students in Northern Ireland, UK
CONCLUSION: IMNs feel that they are the most appropriate professionals to design/deliver HPV education for 15-17 year old students. National policy change, based on collaboration between the Public Health Agency and Education Authority, is a key factor in facilitating IMNs to implement this school-based HPV education intervention.PMID:37543445 | DOI:10.1016/j.vaccine.2023.07.066
Source: Vaccine - August 5, 2023 Category: Allergy & Immunology Authors: Terri Flood Marian McLaughlin Ciara M Hughes Iseult M Wilson Source Type: research

Prevention and control of HPV and HPV-related cancers in France: the evolving landscape and the way forward - a meeting report
This report covers some critical findings, key challenges, and future steps to improve the status of HPV prevention and control measures in the country.PMID:37537651 | DOI:10.1186/s12919-023-00271-0
Source: Cancer Control - August 3, 2023 Category: Cancer & Oncology Authors: Dur-E-Nayab Waheed Catherine Weil Olivier Didier Riethmuller Eduardo L Franco Jean Luc Pr étet Marc Baay Nubia Munoz Alex Vorsters Source Type: research

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Data quality in an HIV vaccine efficacy clinical trial in South Africa: through natural disasters and with discipline
CONCLUSIONS: In the age of infectious and climate disaster risks, trials may benefit from simple study designs and trial-related documents. To optimise protocol adherence, sponsors and sites should consider ongoing training, and routinely review deviation reports with a view to adjusting processes. These data quality lessons may inform future trial design, training and implementation.TRIAL REGISTRATION: HVTN 702 was registered with the South African National Clinical Trials Register (DOH-27-0916-5327) and ClinicalTrials.gov ( NCT02968849 ).PMID:37355583 | DOI:10.1186/s12874-023-01967-9
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Fatima Laher Mookho Malahleha Shelly Ramirez William Brumskine Kennedy Otwombe Zoe Moodie Mary Allen Source Type: research

Protocol for Classification Single-Cell PBMC Types from Pathological Samples Using Supervised Machine Learning
Methods Mol Biol. 2023;2673:53-67. doi: 10.1007/978-1-0716-3239-0_4.ABSTRACTPeripheral blood mononuclear cells (PBMC) are mixed subpopulations of blood cells composed of five cell types. PBMC are widely used in the study of the immune system, infectious diseases, cancer, and vaccine development. Single-cell transcriptomics (SCT) allows the labeling of cell types by gene expression patterns from biological samples. Classifying cells into cell types and states is essential for single-cell analyses, especially in the classification of diseases and the assessment of therapeutic interventions, and for many secondary analyses. M...
Source: Mol Biol Cell - May 31, 2023 Category: Molecular Biology Authors: Minjie Lyu Lin Xin Huan Jin Lou T Chitkushev Guanglan Zhang Derin B Keskin Vladimir Brusic Source Type: research

Communication strategies to improve human papillomavirus (HPV) immunisation uptake among adolescents in sub-Saharan Africa: a systematic review and meta-analysis
Conclusion HPV vaccine communication is critical in ensuring that the community understands the importance of vaccination. The most effective communication strategies included those which educate the population about the HPV vaccine, facilitate decision-making on vaccine uptake and community ownership of the vaccination process immunisation. PROSPERO registration number CRD42021243683.
Source: BMJ Open - April 3, 2023 Category: General Medicine Authors: Oketch, S. Y., Ochomo, E. O., Orwa, J. A., Mayieka, L. M., Abdullahi, L. H. Tags: Open access, Communication Source Type: research

Feasibility of using an app-based coaching intervention to improve provider communication about HPV vaccination
Transl Behav Med. 2023 Mar 31:ibad002. doi: 10.1093/tbm/ibad002. Online ahead of print.ABSTRACTProvider communication training is effective for increasing HPV vaccination rates among U.S. adolescents. However, such trainings often rely on in-person meetings, which can be burdensome for providers and costly to implement. To evaluate the feasibility of Checkup Coach, an app-based coaching intervention, to improve provider communication about HPV vaccination. In 2021, we offered Checkup Coach to providers in 7 primary care clinics in a large integrated delivery system. Participating providers (n = 19) attended a 1-h interacti...
Source: Cancer Control - March 31, 2023 Category: Cancer & Oncology Authors: Brigid K Grabert Annie-Laurie McRee Nora B Henrikson Jennifer Heisler-MacKinnon Paula R Blasi Consuelo M Norris Matthew B Nguyen John Dunn Mary Catharine McKeithen Melissa B Gilkey Source Type: research

TLimmuno2: predicting MHC class II antigen immunogenicity through transfer learning
Brief Bioinform. 2023 Mar 23:bbad116. doi: 10.1093/bib/bbad116. Online ahead of print.ABSTRACTMajor histocompatibility complex (MHC) class II molecules play a pivotal role in antigen presentation and CD4+ T cell response. Accurate prediction of the immunogenicity of MHC class II-associated antigens is critical for vaccine design and cancer immunotherapies. However, current computational methods are limited by insufficient training data and algorithmic constraints, and the rules that govern which peptides are truly recognized by existing T cell receptors remain poorly understood. Here, we build a transfer learning-based, lo...
Source: Briefings in Bioinformatics - March 24, 2023 Category: Bioinformatics Authors: Guangshuai Wang Tao Wu Wei Ning Kaixuan Diao Xiaoqin Sun Jinyu Wang Chenxu Wu Jing Chen Dongliang Xu Xue-Song Liu Source Type: research

Feasibility and acceptability of nationwide HPV vaccine introduction in Senegal: Findings from community-level cross-sectional surveys, 2020
PLOS Glob Public Health. 2022 Apr 6;2(4):e0000130. doi: 10.1371/journal.pgph.0000130. eCollection 2022.ABSTRACTIn Senegal, cervical cancer is the most common cancer among women and the leading cause of morbidity and mortality from all cancers. In 2018, Senegal launched a national human papillomavirus (HPV) vaccination program with Gavi, the Vaccine Alliance (Gavi), support. HPV vaccination was incorporated into the national immunization program as a two-dose schedule, with a 6-12-month interval, to nine-year-old girls via routine immunization (RI) services at health facilities, schools and community outreach services throu...
Source: Cancer Control - March 24, 2023 Category: Cancer & Oncology Authors: Reena H Doshi Rebecca M Casey Nedghie Adrien Alassane Ndiaye Timothy Brennan Jerlie Loko Roka Awa Bathily Cathy Ndiaye Anyie Li Julie Garon Ousseynou Badiane Aliou Diallo Anagha Loharikar Source Type: research

TLimmuno2: predicting MHC class II antigen immunogenicity through transfer learning
Brief Bioinform. 2023 Mar 23:bbad116. doi: 10.1093/bib/bbad116. Online ahead of print.ABSTRACTMajor histocompatibility complex (MHC) class II molecules play a pivotal role in antigen presentation and CD4+ T cell response. Accurate prediction of the immunogenicity of MHC class II-associated antigens is critical for vaccine design and cancer immunotherapies. However, current computational methods are limited by insufficient training data and algorithmic constraints, and the rules that govern which peptides are truly recognized by existing T cell receptors remain poorly understood. Here, we build a transfer learning-based, lo...
Source: Briefings in Bioinformatics - March 24, 2023 Category: Bioinformatics Authors: Guangshuai Wang Tao Wu Wei Ning Kaixuan Diao Xiaoqin Sun Jinyu Wang Chenxu Wu Jing Chen Dongliang Xu Xue-Song Liu Source Type: research

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Multi-level quality improvement strategies to optimize HPV vaccination starting at the 9-year well child visit: Success stories from two private pediatric clinics
Hum Vaccin Immunother. 2023 Feb 16:2163807. doi: 10.1080/21645515.2022.2163807. Online ahead of print.ABSTRACTHPV vaccination rates remain far below goal, leaving many adolescents unprotected against future HPV-related cancers. Starting HPV vaccine at age 9 may improve timely preteen vaccination. The "HPV Vax at 9" Quality Improvement intervention paired HPV vaccination with 9- and 10-year well child visits and was piloted at two pediatric clinics (n = 9 sites) in Washington between 2018 and 2022. Supporting interventions included standardized immunization schedule posters in exam rooms, electronic medical record supports,...
Source: Cancer Control - February 17, 2023 Category: Cancer & Oncology Authors: Sherri Zorn Gabrielle Darville-Sanders Thuy Vu Amy Carter Katie Treend Char Raunio Anjali Vasavada Source Type: research

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